Author Topic: EA antidotes..  (Read 6336 times)


  • Jr. Member
  • **
  • Posts: 28
EA antidotes..
« on: April 28, 2010, 02:47:45 PM »
here is pretty much every drug thats been tried to treat EA.please share your experiences(post SSRI cases) if youve tried any of them


Cyproheptadine is an antihistamine with antiserotonergic properties that has been reported for over a decade to reverse antidepressant-induced sexual dysfunction. Only case reports and case series attest to its efficacy.[13,42-44] Effective doses range from 2mg to 16mg. In the most recent and largest case series, 12 of 25 patients described improvement in sexual function when treated with cyproheptadine (mean dose, 8.6mg).[13] Anorgasmia is the sexual side effect most often reported to be alleviated by cyproheptadine. Cyproheptadine is effective when taken either on an as-needed basis (typically, 1 to 2 hours before intercourse) or on a regular basis.

However, cyproheptadine's utility is often limited by its potential side effects. Excessive sedation and the reversal of the therapeutic effect of the antidepressant are major problems that limit its usefulness. Effectively treated depression and bulimic symptoms have been reported to reemerge soon after cyproheptadine was started.[42,45-48] This reversal of therapeutic effects is itself reversible upon discontinuation.

Buspirone is a serotonin-IA partial agonist typically prescribed to treat persistent anxiety. One case series reported that buspirone reversed both decreased sexual interest and orgasmic dysfunction caused by SSRIs.[49] Most patients using buspirone to treat sexual dysfunction take it daily. The dosage is the same as that used for anxiety (15mg to 60mg daily). The mechanism of action of buspirone in treating sexual dysfunction may be reduction of serotonergic tone via stimulation of presynaptic autoreceptors or the alpha-2 antagonist effects of one of buspirone's major metabolites, 1-pyrimidinylpiperazine.

Nefazodone and mianserin are antidepressants with strong postsynaptic blocking properties. In one case report, nefazodone 150mg taken 1 hour prior to sexual activity completely reversed sertraline-induced anorgasmia.[50] Mianserin, an antidepressant with 5HT-2 and alpha-2 adrenergic antagonist properties, is available in many countries but not in the US. It has been reported to reverse serotonin reuptake inhibitor-induced sexual dysfunction in 9 of 15 patients.[51] Mirtazapine is similar in its biological activity to mianserin and might also be effective in reversing sexual side effects. No case reports or case series have yet been published attesting to this, although clinicians have described such an effect. The putative capacity of mianserin and mirtazapine to reverse sexual side effects can be attributed either to their serotonergic activity or presynaptic alpha-2 activity.

Amantadine, a dopamine agonist, is used both as an antiviral agent and as a treatment for Parkinson's disease. It has been shown in a number of small case series to reverse anorgasmia.[13,52-54] Reported effective doses have ranged between 100mg to 400mg taken either on a daily or as-needed basis. In the most recent case series, 8 (42%) out of 19 patients with SSRI-induced sexual dysfunction improved with amantadine 200mg daily.[13] Given dopamine's consistent effect as a neurotransmitter involved in sexual arousal, a number of other dopamine agonists have been explored as treatments for sexual side effects.[2,55,56]

Bupropion is another commonly touted antidote for SSRI-induced sexual dysfunction.[57,58] It is assumed that the mechanism of action by which bupropion reverses sexual side effects is its weak dopamine agonism. The evidence for bupropion's efficacy is scant, except for unpublished, anecdotal reports, one case report,[57] and a case series[58] in which 31 (66%) of 47 patients showed improvement when bupropion was added to the regimen along with the serotonergic antidepressant. Most patients (18/31) with a successful outcome responded to as-needed use of bupropion 75mg to 150mg. Libido, arousal, and orgasmic difficulties were all effectively reversed. Fifteen percent of treated patients stopped taking bupropion because of its stimulation side effects. It is unclear whether bupropion doses need to be somewhat lower than usual when added to fluoxetine or paroxetine, to compensate for pharmacokinetic interactions resulting in increased bupropion levels.[59]

Stimulants, such as methylphenidate, D-amphetamine, and pemoline, are reported to reverse a variety of sexual side effects caused by SSRIs or MAOIs.[60-62] Low doses of 10mg-25mg of methylphenidate or D-amphetamine have been effective. One should add stimulants to an MAOI with extreme caution because of the risk of a hypertensive episode. However, use of an MAOI/stimulant combination has been shown to be safe in a case series.[63] SSRI/stimulant combinations show no similar risks.

Yohimbine is available with or without a prescription (and with unclear purity) in health food stores. It is an alkaloid from the bark of Corynanthe yohimbi (family, Rubiaceae) and has been used for decades to reverse erectile dysfunction.[64-66] Its efficacy in treating sexual dysfunction may be associated with its ability to block presynaptic alpha-2 adrenergic sites, leading to enhanced adrenergic tone.[65] A variety of sexual side effects have been reported to be alleviated by yohimbine in doses ranging from 2.7mg to 16.2mg daily, prescribed either on a regular 5.4mg 3 times daily basis or on an as-needed basis with single doses up to 16.2mg.[13,67-69] In the largest case series, 17 (81%) of 21 patients showed improvement of sexual side effects when treated with yohimbine (mean dose, 16.2mg).[12]

Typical side effects associated with yohimbine include anxiety, nausea, flushing, urinary urgency, and sweating. Yohimbine has been the subject of the only double-blind, placebo-controlled study to evaluate treatment of sexual dysfunction occurring as a drug side effect.[27] Unfortunately, the placebo effect was marked, showing a minimal drug-placebo difference with yohimbine given at a dose of 5.4mg 3 times daily. Yohimbine is also available in lower potency without a prescription. The purity, potency, and safety of these preparations, however, are unknown.

Bethanechol is a cholinergic agonist that has occasionally been useful in reversing sexual dysfunction associated with TCAs and MAOIs.[70-73] Typical doses are 10mg to 20mg as needed or 30mg to 100mg daily in a divided dose. Potential side effects with bethanechol include diarrhea, cramps, and diaphoresis. No reports have evaluated or suggested the efficacy of bethanechol for treating SSRI-induced sexual side effects.

Gingko biloba is an herbal extract reported to reverse a variety of sexual dysfunctions associated with antidepressants. Information about gingko's ability in this regard is derived from the experience of 1 clinician presenting a large case series.[74] The response rate was greater than 80%, with doses ranging from 60mg twice daily to 120mg twice daily (mean daily dose, 207mg). Reported side effects include gastrointestinal upset, lightheadedness, and stimulation effects. Because gingko may inhibit platelet-activating factor, caution should be used in considering its use by any patient with a bleeding diathesis. The mechanism by which gingko might alleviate sexual dysfunction is unknown.


  • Jr. Member
  • **
  • Posts: 28
Re: EA antidotes..
« Reply #1 on: May 21, 2010, 10:55:27 AM »
hokay,has anybody tried the much touted antidote amantadine or cabergoline(both dopamine agonists..dopamine has proven positive influence on orgasm)?..theyre both FDA approved for parkinsionism and hyperprolactinemia but theyve been used for enhancing sexual pleasure for more than a decade nowh

   the good thing with these is that one doesnt have to take them regularly..amantadine(symmetrel) can be taken around 3-4 hrs b4 sexual activity at a dose of 100 mg.the problem is it isnt an over the counter drug.

 my buspirone trial is nearly over..whilst it didnt improve my orgasms,my PE is much better and the feeling of satisfaction after ejaculation is back as well..again i cant say it wont work for any one else because the usual doses in responding patients in trials were around 45-50 mg.i could go above 20-25 because of the nausea going to try to give it another week..

  after that ill probably give both bupropion(wellbutrin) and nefazodone(serzone) a try..while ideally both should be taken for 2 weeks,some trials show positive results after single doses of 150 mg taken 2 hrs before sex.

 nearly all the drugs in the above post are used by psychiatrists with buspirone,bupropion being the first drug doesnt work for all of them..its usualy hit and trial with periactin,symmetrel and urecholine being 2nd line.


  • Jr. Member
  • **
  • Posts: 36
Re: EA antidotes..
« Reply #2 on: May 25, 2010, 05:57:11 AM »

 my buspirone trial is nearly over..whilst it didnt improve my orgasms,my PE is much better and the feeling of satisfaction after ejaculation is back as well.

just to make sure, you're speaking of intercourse here and not masturbation?

To reply to your OP, I tried Gingko biloba, it didn't have any effect on me. Also tried Yohimbine, which gave a bit sronger erection than usual but nothing more.


  • Administrator
  • Hero Member
  • *****
  • Posts: 450
Re: EA antidotes..
« Reply #3 on: April 10, 2020, 05:54:37 AM »
here is pretty much every drug thats been tried to treat EA.please share your experiences(post SSRI cases) if youve tried any of them

Cyproheptadine Amantadine Acute trials for both. No positive effect.

Gingko biloba - Taken this over long periods. Nothing.

Bupropion methylphenidate - Had month or two trials of both of these. Nothing positive.

Yohimbine - I tried it and found myself very sensitive to it, particularly at first. The suggested does of 16mg is way too much for me. About 3mg tended to improve erections. I took it daily for a while, and didn't like the effect. Chills and jittery. Also, I'd have trouble sleeping if I used it for sex at night.

Nefazodone  Never tried it. It was on my list of interest, though.

Buspirone I may be starting this soon. I'm talking with a doctor now. It's very cheap. Reportedly has minimal negative side effects, at least relative to anti depressants.


  • Newbie
  • *
  • Posts: 2
Re: EA antidotes..
« Reply #4 on: July 05, 2020, 08:54:49 PM »
buspirone - Caused severe lightheadedness, had to stop. Did not improve sexual dysfunction.
Gingko biloba - Took it in the context of tea with gingko biloba and gotu kola. Slight mood life, but no other positive effect.