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Just found a very detailed anorgasmia presentation made in 2018:
https://grandroundsinurology.com/wp-content/uploads/2018/09/2018-9-12-SDU-Innovations-Male-Anorgasmia-From-No-To-Go-FINAL-Pastuszak.pdf


Here are all the pharmacology possbile treatments that have been listed:

Cabergoline
Bupropion
Oxytocin
Cyproheptadine
Buspirone
Pseudoephedrine
Ephedrine
Midodrine
Yohimbine
Amantadine
Apomorphine
Bethanechol
Loratadine
Reboxitine

Updated Keywords to search in Combination:

Quote
1. OCD (Obsessive Compulsive Disorder), Parkinsons, Tourettes, Trichotillomania, Parkinsons, Multiple Sclerosis, Bipolar, Depression, Anhedonia, Schizophrenia
2. NDMA, Histamine, NAC (N-acetylcysteine), Histidine, GABA, Sarcosine
3. DXM, Cyproheptadine, Cabergoline, Bupropion, Oxytocin, Buspirone, Pseudoephedrine, Ephedrine, Midodrine, Yohimbine, Amantadine, Apomorphine, Bethanechol, Loratadine, Reboxitine
4. Anorgasmia, Orgasm, Ejaculation, Ejaculatory, Sexual, Sexual Dysfunction, Libido

Now I know this keyword list is getting bigger and bigger and a lot of people have tried some of these. But the main thing you want to find connections with, is if any of them have effects on NDMA, Histamine, and  OCD. I believe these are the main factors to do with ejaculatory anhednoia.

Remember I'm on day 1 of my 5g of NAC. Lots of energy it seems lol.

But what this all comes down to if you want to get down to the possible cure/solution.

Try and take 2400mg (or more) of NAC a day for 3 months and report back here on any improvement with ejaculatory anhedonia and any other observations you see (whatever they may be, like anhedonia, aniexty, happiness, motivation, food tasting better, lessening of addictions etc..).
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https://www.ncbi.nlm.nih.gov/pubmed/25502486

Quote
As-needed use of cyproheptadine for treatment of selective serotonin reuptake inhibitor-related female anorgasmia.

https://www.ncbi.nlm.nih.gov/pubmed/8919332
Quote
Successful treatment of citalopram-induced anorgasmia by cyproheptadine.

This is the first report of the use of cyproheptadine to treat anorgasmia induced by citalopram, a highly selective serotonine reuptake inhibitor (SSRI). Total anorgasmia of a 47 year-old man who suffered from severe unipolar major depression was successfully treated without adverse effects. This case strengthens the impression that anorgasmia associated with SSRIs is related primarily to the serotonine reuptake inhibition and not to various receptor bindings of different compounds.

https://www.ncbi.nlm.nih.gov/pubmed/8665544
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Cyproheptadine treatment of sexual dysfunction induced by serotonin reuptake inhibitors.

Treatment of serotonin reuptake inhibitors (SRIs) is associated with sexual dysfunction. The cause of this dysfunction is unclear but may be related to stimulation of the serotonergic system. In the present article, we describe seven patients in whom iatrogenic sexual dysfunction induced by SRIs was treated with cyproheptadine, a 5HT-2 antagonist with antihistaminergic and adrenolytic properties. Seven obsessive-compulsive male patients, aged 29-54 years, who developed sexual dysfunction following treatment with SRIs (fluoxetine, fluvoxamine, and clomipramine) were instructed to take cyproheptadine (4-12 mg) 1-2 h before commencing sexual activity. Five of the seven patients displayed improvement in sexual function, although the improvement was transitory in two. The two remaining patients did not respond. All patients exhibited sedation on the day following cyproheptadine administration. Our preliminary observation suggests that some patients with sexual dysfunction associated with SRI treatment, mainly decreased libido and anorgasmia, may benefit from cyproheptadine administration. The role of 5HT-2 antagonists in SRI-induced sexual dysfunction merits further investigation.

https://www.ncbi.nlm.nih.gov/pubmed/7952994
Quote
Successful treatment of fluvoxamine-induced anorgasmia by cyproheptadine.

https://www.ncbi.nlm.nih.gov/pubmed/1592848
Fluoxetine-induced yawning and anorgasmia reversed by cyproheptadine treatment.

https://www.ncbi.nlm.nih.gov/pubmed/1920732
Quote
Reversing anorgasmia associated with serotonin uptake inhibitors.

MeSH terms, Substances
Clomipramine/adverse effects
Cyproheptadine/therapeutic use*

Quote
Reversal of antidepressant activity of fluoxetine by cyproheptadine in three patients.

Three male patients are described in whom anorgasmia developed during treatment with fluoxetine for depression. During attempts to treat the anorgasmia with cyproheptadine, all three patients suffered a relapse of depressive symptoms. The possible mechanism of this effect is discussed in relation to serotonergic systems.

https://www.ncbi.nlm.nih.gov/pubmed/2880654
Quote
Cyproheptadine and drug-induced anorgasmia.

https://www.ncbi.nlm.nih.gov/pubmed/3771824
Quote
Cyproheptadine for imipramine-induced anorgasmia.

https://www.ncbi.nlm.nih.gov/pubmed/3697592
Quote
Cyproheptadine and antidepressant-induced anorgasmia.

https://www.ncbi.nlm.nih.gov/pubmed/4039897
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Reversal of MAOI-induced anorgasmia with cyproheptadine.



There's loads of studies, many from late 1980's on this anti-histmaine cyproheptadine helping reverse anorgasmia.

I'm assuming the anti-histamine is not available as much or has been replaced by newer ones.

But cyproheptadine is a new keyword! Google it in combinations with other keywords and see if we can find anything!

Updated keywords people should be researching in combinations:

Quote
1. OCD (Obsessive Compulsive Disorder), Parkinsons, Tourettes, Trichotillomania, Parkinsons, Multiple Sclerosis, Bipolar, Depression, Anhedonia, Schizophrenia
2. NDMA, Histamine, NAC (N-acetylcysteine), Histidine, GABA, DXM, Cyproheptadine
3. Anorgasmia, Orgasm, Ejaculation, Ejaculatory, Sexual, Sexual Dysfunction, Libido


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https://www.ncbi.nlm.nih.gov/pubmed/2211550

Quote
Reversal of fluoxetine-induced anorgasmia by cyproheptadine in two patients.

Abstract
The authors report two cases of ejaculatory dysfunction induced by fluoxetine. Cyproheptadine, an antihistaminic and antiserotonergic drug, restored sexual function in each case. Possible mechanisms of fluoxetine-induced anorgasmia are presented and treatment options are reviewed.

I don't know how the antihistaminic and antiserotonergic drug reversed their anorgasmia. The point is, it is a drug that effects histamine levels, and cured 2 patients anorgasmia.

Just trying to find connections.

Okay according to this: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816679/

Quote
Cyproheptadine, an anti-histamine known to increase brain serotonin levels, has been studied to treat DO related to SSRI use (5, 43, 44).

The number (44) is reference to that study, but I don't know how to get the full text.

But even though the abstract is saying antiserotonergic. The person referring to that study (and 2 other studies) is saying it increases the brain serotonin levels.

So maybe rebound effects, body trying to make more of what is being suppressed.

Like I said I'm not an expert. But biggest point here is an anti-histamine cured anorgasmia in 2 patients, i.e. related to histamine in the brain.
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Updated Buzzwords people should be researching in combinations:

1. OCD (Obsessive Compulsive Disorder), Parkinsons, Tourettes, Trichotillomania, Parkinsons, Multiple Sclerosis, Bipolar, Depression, Anhedonia, Schizophrenia
2. NDMA, Histamine, NAC (N-acetylcysteine), Histidine, GABA, DXM
3. Anorgasmia, Orgasm, Ejaculation, Ejaculatory, Sexual, Sexual Dysfunction, Libido
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Don't forget this tidbit from my other thread 2 years ago:

Quote
Quote
NMDA can also enhance GABA release and releases pregnenolone and IGF-1; which can have pro-anabolic effects altogether, AND, NMDA acts as a major gonadotropic signaler, where it can massively increase testosterone and other sex hormones.

This is interesting. I remember years ago on another popular health site, that a guy started a thread on Ejaculatory Anhedonia. It became a huge mega thread, and he was finally able to cure himself by taking GABA (didn't work for me though).

What is also interesting about the above passage is it enhances the release of pregnenolone. I remember when I took pregnenolone, I would ejaculate very fast, and my penis head did become more sensitive and pleasurable. I thought pregnenolone could have been the key for me at one point, but I couldn't take it anymore because it worsened my peyronies disease.

But from the above passage, it's saying NDMA enhances GABA, pregenolone, and testosterone as well as other sex hormones. So NMDA seems like an all rounder for influencing sexual function it sounds like.

I think I was referring to the hisandher thread where the guy cured himself with GABA.

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Just an update, it's been an 1h15m since I took 5g of NAC. Just went for a poo and had some diarrhea and could smell that NAC smell. However I can't say it was bad diarrhea, as I was constipated from eating some really spicy chicken wings and oreos yesterday.

Also I can feel I have absorbed my supplements (& NAC), because my brain has woken up more.

I usually have 2 poos in the morning when my eating routine is normal. One first thing, one a couple of hours later. So I'm hoping as long as I take all my supplements + 5g NAC in the morning, it'll come out with the second poop.

Lastly, this wasn't a painful or burning poop/diarrhea, unlike what you get with Vitamin C (ascorbic acid) if you take too much. It was more like an addition to my normal poop.

Anyway we'll see over the days, but it wasn't a big deal. Just an observation, and maybe a warning that if people want to try as high doses as I'm doing, start your experiment on a day off where you have access to your toilet, rather than when you have to journey to work.

Also don't forget I may tolerate higher doses better than other people, as I've been on a very good supplementation stack I've grown over the years for myself. So if your not taking extra vitamin c, e, d, a, k, etc... and minerals like zinc or liquid magnesium like I am, you tolerance might be lower.
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Look at one of the things I mentioned just in case in my thread 2 years ago:

http://ejaculatoryanhedonia.com/index.php/topic,1980.msg6098.html
Quote
I forgot to mention, a couple of days earlier, I did take 2 Night Nurse, and an anti histamine to help me sleep and unblock my nose, just in case that had anything to do with my orgasm.

Did I get histamine rebound that caused me a very low quality orgasm/pleasure?

Also here's some other tidbits from that thread:

Quote
DXM use and intense orgasms?

Quote
SWIM is a female that occasionally enjoys recreational use of DXM. After awhile it became apparent to SWIM that a couple of days after dosing SWIM could achieve the most spectacular orgasms of her life, sometimes multiple.

Quote
DXM is an NMDA antagonist. NMDA antagonists have been scientifically shown to be able to reverse tolerance, have antiaddictive effects, and even to prevent the development of tolerance when administered with other drugs. It also increases the concentration of Dopamine in the brain by blocking PCP-2 receptors.

I thought there might be a connection there, as FOS has been proven to increase "levels of BDNF & NMDA receptor subunits in the hippocampus" in rats. But then after googling "antagonist", it means inhibit. So DXM inhibit NMDA, so the opposite of what the fiber does.

However she does say "after awhile it became apparent to SWIM that a couple of days after dosing". So this might make sense, as the brain tries to rebalance itself out from the suppression of NMDA, by producing more NMDA or more NMDA receptors or something.

Remember I'm no expert, just trying to make connections.

But I think our problem is all related to NMDA and low Histamine in the brain.

And don't forget Histamine in the brain has been linked to a variety of conditions, such as Parkinson's, multiple sclerosis, autism and obsessive compulsive disorder, as well as Tourette syndrome.

So buzzwords people need to be researching in combinations are:

Quote
1. OCD (Obsessive Compulsive Disorder), Parkinsons, Tourettes, Trichotillomania, Parkinsons, Multiple Sclerosis, Bipolar, Depression, Anhedonia, Schizophrenia
2. NDMA, Histamine, NAC (N-acetylcysteine), Histidine
3. Anorgasmia, Orgasm, Ejaculation, Ejaculatory, Sexual, Sexual Dysfunction, Libido
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Look what I just found googling NAC Histamine.

https://www.ncbi.nlm.nih.gov/pubmed/2409763
Quote
Histamine secretion induced by N-acetyl cysteine.

The mucolytic drug N-acetyl cysteine has been shown to release histamine from cultured mouse mast cells and from human basophils. At neutral pH the release was moderate and non-cytotoxic. If the acidity of the drug was not neutralized, this histamine release was markedly potentiated, but was then associated with a reduction in the viability of the cells. However, the high level of release could not be reproduced by simply exposing the cells to an acidic medium. The results are discussed in terms of a possible mechanism for the adverse reactions sometimes observed during N-acetyl cysteine therapy.

https://www.ncbi.nlm.nih.gov/pubmed/1725675
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Effects of N-acetylcysteine on histamine release by sodium fluoride and compound 48/80 from isolated rat mast cells.

N-acetylcysteine (NAC) enhances the release of histamine induced by the fluoride-calcium system but not by compound 48/80. After preincubation of the cells for 2 h at room temperature (RT) as well as at 37 degrees C, NAC was found to enhance histamine release also when induced by compound 48/80. Both fluoride treatment and prolonged incubation at 37 degrees C (but not at RT) for 2 h decreased the ATP content of the cells. NAC was found to counteract the fall in ATP caused by prolonged incubation of the cells at 37 degrees C but not when induced by exposure to sodium fluoride. The results do not favor the concept that free radicals generated by fluoride treatment are responsible for the subsequent sensitivity of the cells to the secretory action of calcium. On the other hand, it cannot be excluded that free radicals generated during prolonged incubation of the cells at 37 degrees C might be involved in the decrease of the sensitivity of the cells to the secretory action of the fluoride-calcium system and of compound 48/80. This is supported by the finding that the presence of NAC not only activated the secretory response but also counteracted the decrease of the cellular ATP content noted following preincubation of the cells for 2 h at 37 degrees C.

Don't forget that study about histamine curing mice of Tourettes like tics and brain histamine being linked to a variety of conditions:

https://news.yale.edu/2017/06/05/tourette-tics-vanish-mice-treated-histamine
Quote
Tourette-like tics vanish in mice treated with histamine | YaleNews
5 Jun 2017 - Histamine's role in immunological reactions such as allergies has been intensively studied, but in recent years the neurotransmitter histamine in the brain has been linked to a variety of conditions, such as Parkinson's, multiple sclerosis, autism and obsessive compulsive disorder, as well as Tourette syndrome.

Don't forget the guy cured his OCD and ejaculatory anhedonia in 2.3 months of 2400mg of NAC.

Don't forget the guy who couldn't orgasm on prozac unless he takes 1x 500mg of l-histidine 30 minutes before sex.

And now we know NAC enhances the release of Histamine secretion.
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Okay the experiment starts today.

I forget a couple of months a go I bought a mini scale for measuring powder off Amazon, so it will be accurate dosing and not just half a teaspoon or teaspoon.

First of all here is my current daily stack I've built over time and has helped me with my general health. As you can see it's mostly covering my essential vitamins/minerals, but each has helped me in improving certain problems/general health except anhedonia, motivation, or ejaculatory anhedonia.

Quote
*2 x Vitamin E* (Healthy Origins - E400)
*1 x 5000 I.U. Vitamin D* (Natures Aid)
*1 x 1g Vitamin C* (Any brand is fine as long as it’s ascorbic acid)
*1 x Vitamin A (3,300 I.U.) + Vitamin D (400 I.U.)* (Holland & Barrett)
*1 x Vitamin K2 (5mg MK4)* (Carlson)
*1 x 25mg Zinc Citrate* (Higher Nature)
*1 x 30mg Pycnogenol* (Natures Aid)
*1 x Ginger* (Natures Aid or Higher Nature)
*1 x B-Complex* (Higher Nature - B-Vital)
*1 x Gingko Biloba* (Higher Nature)
*1 x Sea Buckthorn Oil* (Natures Aid)
*1 small cap or 1/2 a big cap of Ionic Magnesium* (Good State)

Now I am going to start high with NAC, and this morning (40 mins ago), I measured out 5g of NAC powder and drank it.
I'm going to keep my Sarcosine at 500mg to avoid the possibility of increased irritation.
If I can tolerate 5g of NAC without problems I'll continue this. If not I've slowly decrease it.

So my experimental daily stack additions for now is:

Quote
5000mg of NAC
500mg of Sarcosine

Note I take all my supplements in one go in the morning.

I'm going to leave buying histidine for now, and see what results this stack produces after 3 months.

I'll keep people updated of what results I experience if any. As for now, I have to try and stick to it daily for 90 days.

So Tuesday 13th August is Day 1.
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https://pdfs.semanticscholar.org/8d1e/c12182c708a18ba433b47073a34011c2ed50.pdf

Quote
Results: Male subjects with OCD had a lower age of first masturbation and first nocturnal ejaculation. Infrequency problem among female and male patients with OCD occurred in 63.6% and 57.1%, respectively. Corresponding figures for PD patients were 36% and 38%. Thus, infrequency problem was more frequent among OCD patients. Sexual avoidance was found in 60.6% of female OCD patients and in 64% of female PD patients. Anorgasmia was detected in 24.2% of the female subjects with OCD.

I can say I started masturbating very young before I could even ejaculate, 5 years old, and use to do it daily and would have dry orgasms all the way up through my childhood to adulthood.

Also I remember younger incidents of OCD, like brushing my teeth for half an hour and pulling out my eye lashes.

https://www.tandfonline.com/doi/full/10.1080/24750573.2018.1472907

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Trichotillomania (TTM) is a disorder characterized by repetitive hair pulling resulting in hair loss and it is usually difficult to treat with a chronic course of illness. Currently, the selective serotonin reuptake inhibitors (SSRIs) are the most frequently prescribed drugs for adults with TTM. Various studies and case reports give mixed results. Therefore, the treatment effectiveness of SSRIs remains uncertain. There is a growing interest regarding the use of glutamatergic agents in obsessive compulsive disorder and obsessive compulsive spectrum disorder. Here, we report an 18-year-old female patient with TTM, which successfully treated with glutamate modulator n-acetylcysteine.

Above is a case where a girl was cured from her trichotillomania with NAC

There's even a testimony on youtube of a girl who suffers from it and explaining how NAC helped her.

https://www.youtube.com/watch?v=1zPXDDNxbdU

Quote
A Turkish study compared the level of sexual satisfaction in OCD and generalized anxiety disorder and found higher incidence of anorgasmia, sexual arousal disorder and sexual avoidance in the OCD group (Aksaray & Yelken 2000).

https://www.ncbi.nlm.nih.gov/pubmed/11354932

Quote
Abstract
This study assessed the effect of obsessive compulsive disorder (OCD) on sexual function. Twenty-three outpatients who met Diagnostic and Statistical Manual of Mental Disorders (DSM-IV; American Psychiatric Association, 1994) diagnostic criteria for OCD were obtained from consecutive cases recruited to Osmangazi University Department of Psychiatry and were compared to a group of 26 generalized anxiety disorder (GAD) female outpatients. Psychiatric, psychological, and sexual information was obtained with the Maudlsey Obsessional-Compulsive Inventory (Hodgson & Rachman, 1977), the State-Trait Anxiety Inventory (Spielberger, Gorsuch, & Lushere, 1970), and the Golombok Rust Inventory of Sexual Satisfaction (Rust & Golombok, 1986). We found that the women with OCD were more sexually nonsensual, avoidant, and anorgasmic than the women with GAD. These data suggest that OCD may be a risk factor for sexual problems in women.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423164/

Quote
Results
Four clinical trials and five case reports/series were identified. Study durations were commonly 12-weeks, using 2,400–3,000 mg/day of NAC. Overall, NAC demonstrates activity in reducing the severity of symptoms, with a good tolerability profile and minimal adverse effects. Currently there are three ongoing randomized controlled trials using NAC for OCD (two adults and one pediatric), and one for excoriation.

Conclusion
Encouraging results have been demonstrated from the few pilot studies that have been conducted. These results are detailed, in addition to a discussion of future potential research.

So we have the OP from longecity who cured his OCD and restored his orgasm after 4 years of ejaculatory anhedonia from NAC in 2 months.

NAC helps people with trichotillomania and OCD.

In one case NAC completely cured one girl of trichotillomania (posted above).

Anorgasmia was found in 51.2% in Women with OCD in one study, and 24.2% in another study.

NAC (& Sarcosine) has been helping me with general anhedonia, enjoying some foods like they taste like they're the bomb (and others I don't like, put down/throw away, whereas before I would have still finished it, and motivation. Only supplements to do this, even after years of taking a well rounded supplement regime.

We've got plenty of connections here.

People should share if they suffer from OCD type symptoms, like needing to check the door is locked a few times before leaving the house, or worrying you've left something on, or needing things to be in a particular way or routine.
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