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Contributing Factors - Physical / Human chorionic gonadotropin hCG
« Last post by Jaderr on August 24, 2019, 10:01:30 PM »
Theoretically hcg generates Lutenising Hormone wich then generates testosterone.
Ive tried to use testosterone, didnt work at all.
So lets try LH. nope, better try hcg because anyway it will improve my LH and testo levels... Get back to you in a couple weeks.
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https://www.ncbi.nlm.nih.gov/pubmed/9466376
Quote
Obsessive-compulsive disorder (OCD) is briefly characterized, and several of the hypothesized neuroanatomical and neurochemical substrates of this etiologically heterogeneous syndrome are noted. Importantly, alterations in the CNS balance of monoaminergic neurotransmitter systems are probably involved in the pathobiology of OCD. Inasmuch as calcium (Ca) concentration regulates neuronal neurotransmitter release, presynaptic Ca deficiencies can disrupt normal neurotransmission. Supporting this, a case report is presented of a subject with intermittent OCD and comorbid cardiac pathology for whose latter condition a regimen of increasing doses of a Ca channel blocker (CCB) greatly exacerbated the OCD. Upon reducing, then discontinuing the CCB dose, the OCD sympomatology was greatly ameliorated. It is suggested that minimal use of CCBs is indicated for OCD subjects and that, if possible, they be substituted with other drugs. In view of the widespread use of CCBs, this cerebral Ca deficiency hypothesis of OCD etiopathogenesis should be further tested by seeking other OCD subjects, especially from cardiology practices.

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salt= sodium-> 5-6g of salt is enough for RDA-> 4g~ of potassium total, most likely you don't get enough from food, at least I take 4g, since RDA is prolly too low, 400mg of magnesium/1g of calcium daily
I always throw salt into the water and try to avoid intake from other sources during a day
take 3g of supplemental potassium
and calcium/magnesium is quite easy to get anyway- poppy seeds and cocoa are 2 good examples of foods where u can get em

Quote
how long did it take to cure your ocd?
2-3 months
pure compulsions tho
what do you mean?
hand washing
mainly
hardcore, till bleeding
lol
are you completely cured of your OCD?
or just heavily reduced?
completely

Quote
potassium chloride XR

talking to some guy who had really bad ocd, cured it via mineral intake, pasting stuff here
3
I always wanted to try naltrexone, but wasn't able to get it.

I too have never heard of NAC and it's benefits until recently. I will say though, I've been waking up with morning wood constantly since upping my dose. And erection hardness is harder.

https://area1255.blogspot.com/2015/01/how-to-upregulate-nmda-receptors-and.html

Quote
Treatment of OCD; Obsessive-Compulsive-Disorder (!) (!)
Treatment of Schizophrenia, and psychotic symptoms induced by low glutamate levels(!) (!).
Regulating dopamine, and potentiating hypothalamic activity - helping to treat infertility, low libido and sexual dysfunctions in both men and women(!)  (!) (!).
Increased fear-learning and long-term consolidation of fear-memory, including fear extinction ; thus adapting to fears and learning to face them better, and more naturally (!) (!).
Decreased anxiety and incidences of depression in some individuals.
Less paranoia, and increased sociability due to increased oxytocin by the glutamate NMDA-channel opening and subsequent interactions between calcium channels and nitric oxide.
Increased vasodilation and workout performance, enhanced nitric oxide levels.(!) (!)
Alleviation of long-term memory issues and active memory disruption.(!) (!)
Restoration of ejaculation process in men(!).

If you click that link above. Then go on this site and click the ! for the URL to the study.

After years of taking a range of supplements and drugs to find a cure with no improvement, I have renewed hope. But time will tell.

I wish you the best on your journey.
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https://www.sciencedirect.com/science/article/pii/S0924933815311597

Quote
Complete Remission of Obsessive Compulsive Disorder After N-acetylcystein Treatment

Introduction
N-acetylcystein (NAC), a precursor to the amino acid cysteine, has been emerging as an interesting add-on treatment in several psychiatric conditions and especially in Obsessive Compulsive Disorder (OCD). These results may be linked to its metabolic profile: antioxidant properties through glutathione production; anti-inflammatory properties; and modulation of the glutamatergic and dopaminergic systems of neurotransmission.

Objectives
Review the potential therapeutic effects of NAC in psychiatry, with main focus on syndromes of the obsessive-impulsive spectrum with report of a clinical case.

Methods
Case report of a patient with OCD and Hoarding disorder, with complete clinical remission after treatment with NAC; bibliographic search using PubMed/MedLine database with the following keywords: n-acetylcysteine; OCD; hoarding.

Results
We report and discuss the case of a 44-year-old man with a diagnosis of Obsessive Compulsive Disorder with orderliness and contamination themes, coupled with Hoarding disorder. The patient experienced gradual though slight improvement with Paroxetine (60 mg/day) to which was subsequently added Risperidone (2 mg/day) with further slight improvement. In combination with the previously given pharmacological agents, NAC (1800 mg/day) was introduced with subsequent complete remission of all symptoms.

Conclusions
Studies suggest that NAC may be useful in the treatment of several psychiatric conditions. Our case report suggests direct relation between treatment with NAC and remission of obsessive and hoarding symptoms. Although encouraging, additional controlled research will be required to ascertain NAC clinical usefulness.

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I had never heard of NAC. However, I have a quite different story and characteristics from you.

From 17 to 31, I was almost always in a big loving rewarding relationship. There were three in that span. And being that close, I actually didn't feel this physical anhedonia that much. I always did when I broke up, but always explained it away as being because of the breakup. And when I would start seeing someone else, I would always have trouble in the beginning with sex, because I simply wasn't feeling the drive. I would always have the story, which I believed, about not being over the previous relationship. And with more time, and more emotional depth with the person, I would be able to perform again. This started to change like two or three years ago, because now I just don't have any drive at all, and for the first time in my adult life I am actually single and planning on staying that way. I would love to see people, but not get too deep. But now the anhedonia and lack of libido shows itself very clearly, to the point where now I don't even seek out women. Which is a shame, because I'm considered a pretty attractive guy and could easily bed many of them.

But the weird thing is that every once in a while, for a period, my sex drive comes back; the feeling comes back; the quality of orgasm comes back to normal, to these intense deep orgasms, and I feel different.

I think of hormones because I have Hashimoto's, and I am in the process of trying to bring that into remission, meaning normalizing the thyroid related antibodies in my blood.

My next step is going to be to try low dose naltrexone, in a few days it arrives.
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https://www.psychologytoday.com/gb/blog/heal-your-brain/201810/nac-the-amino-acid-turns-psychiatry-its-head
Quote
The intriguing thing about NAC to me is that it’s of great interest to neuroscience researchers. There have been many studies of this compound, including neuroimaging studies, and it has been investigated in innumerable disorders—depression, bipolar disorder, OCD, PTSD, schizophrenia, addiction, eating disorders, Alzheimer’s disease, and addiction (Berk). NAC also has established medical uses as an anti-inflammatory medicine in cases of acetaminophen overdose in preventing liver failure. Clinical trials have been promising in many (but not all) disorders where it has been studied (Berk). Clearly, there’s a need for more research studies, both more clinical trials in different disorders, and more basic research to see how NAC works in the brain.

Why does NAC help many people with psychiatric diagnoses? Why does it work across so many conditions? This is the intriguing thing, in my eyes. Are its benefits a result of its anti-inflammatory effects?  Or some other mechanism? On a clinical level, in day-to-day work with patients, NAC seems to help with ruminations, with difficult-to-control extreme negative self-thoughts. Such thoughts are common in depression and anxiety disorders, and also in eating disorders, schizophrenia, OCD, etc. etc. I’ve seen it help patients with such disorders when many other things, medicines or psychotherapies, have not helped much.

Just putting it out there, as the title of my thread might make people think it doesn't apply to them. But NAC has be proven to show benefits in a whole range of mental conditions, not just OCD. So it seems like it really does something in your brain that helps it reduce and even cure certain mental conditions.

As an update. I've reduced my dosage to 3000mg. Other than me being on top of the freaking world yesterday, blaring music in my car, driving for fun and not just work, on a life high (took 5g of NAC). Also my poops did stink of NAC too. The main reason I lowered it, is because filling up my little measuring scale overfloweth, and I think 3g would be an effective dose (is still 6 times as much as what I use to take), and the powder will last a month.

Also I masturbated yesterday, and I feel like I felt some build up of pleasure, but it was too subtle to tell.

Really I need to be taking these high doses while not jacking off or having sex for 3 months, and then bust a nut.

Things I will say I noticed from yesterday:
Quote
1. I've started holding my breath as I get toward the end of masturbating. I remember doing this when I was younger trying to get that orgasm, but I haven't done that for the last 17 years. So it's an odd phenomenon that has reappeared all of a sudden.

2. I was lasting freaking long. Like I'm no premature ejaculator, I think most of my supplements allow me to last a good amount of time these days, I don't suffer from PE. But this was sort of like a delayed ejaculation or inability to actually come (something I suffered in the past as well), but wasn't. It was more like, I just needed to do more than the usual rubbing to bust one out. I wonder if this is something to do with build up of orgasm, and my bodies restoring the initial stages again?

3. Erections were harder.

4. My dick is RED. I nearly forget this one. But my dick definitely seemed more red than usual. Like a hot flush red.

5. Memories are coming back. Not like super clear vivid memories. But like just realizing, oh yeah I remember when I was younger I use to pull my eye lashes out, oh yeah I remember when I was younger and masturbating I use to hold my breath toward the end to try and orgasm. Otherwise before I totally forget I did any of these things.


Lastly I hope this is the cure. There have been some great things happening to me. We're actually moving in a direction where there have been changes to myself. However I have yet to experience a decent restoration of sexual pleasure and orgasm, but I'll keep you guys updated.

Day 2: 3g NAC
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Just throwing this out there, I'm not trying to derail your thread, I hope someone can answer you.

But I not sure how much our condition has to do with hormones. Embarrassingly to say I started masturbating at a very young age of 5 years old, and use to do it daily until the age of 16. I remember I use to have dry orgasms all the time, I wasn't able to ejaculate until very later on. I also hit puberty really late, last one to grow hair on my legs, never grew a proper snail trail, still don't have a full grown beard (on my cheeks), I'm 31 btw, and most of my body hair and beard was facilitated by minoxidil because I hated being baby faced. Only since 2016 I've been able to grow a semi decent beard that makes me look like a man, but up until 2015 when I was 27, you could have mistaken me for an 18 year old.

So I could definitely see how hormones may play a part, as early masturbation has stunted my puberty, and thus may be a cause of EA.

However this doesn't explain how a 5 year old onwards could experience multiple dry orgasms, as their hormone profile would not be anyway near to a healthy teenager going through puberty or a healthy man.

i.e. How much did hormones really play, when I was masturbating at 5 years old and having dry orgasms?

Then again they might have because I never went through puberty properly. So maybe my orgasms were using a certain hormone up that was needed for proper puberty.

I will say taking pregnenolone gave me some pleasurable sensations back, and I do believe I suffer from some type of adrenal fatigue. However I can't take pregnenolone cause it worsens my peyronies.

The biggest connection I've found recently is NAC. Even after years of covering all my vitamins/minerals with good quality supplements and doses, along with taking gingko, ginger, pycnogenel, sea buckthorn oil. I've never been able to cure my OCD, Anhedonia, or Ejaculatory Anhedonia.

Since taking the combo on NAC+Sarcosine, I've had dramatic changes in my Anhedonia and Drive.

I would recommend just trying NAC in 2400mg+ doses, and see if it makes a different to your societal anhedonia.

The thing with NAC is it practically helps all mental conditions, whichever one you personally suffer from.

https://www.psychologytoday.com/gb/blog/heal-your-brain/201810/nac-the-amino-acid-turns-psychiatry-its-head

Quote
The intriguing thing about NAC to me is that it’s of great interest to neuroscience researchers. There have been many studies of this compound, including neuroimaging studies, and it has been investigated in innumerable disorders—depression, bipolar disorder, OCD, PTSD, schizophrenia, addiction, eating disorders, Alzheimer’s disease, and addiction (Berk). NAC also has established medical uses as an anti-inflammatory medicine in cases of acetaminophen overdose in preventing liver failure. Clinical trials have been promising in many (but not all) disorders where it has been studied (Berk). Clearly, there’s a need for more research studies, both more clinical trials in different disorders, and more basic research to see how NAC works in the brain.

Why does NAC help many people with psychiatric diagnoses? Why does it work across so many conditions? This is the intriguing thing, in my eyes. Are its benefits a result of its anti-inflammatory effects?  Or some other mechanism? On a clinical level, in day-to-day work with patients, NAC seems to help with ruminations, with difficult-to-control extreme negative self-thoughts. Such thoughts are common in depression and anxiety disorders, and also in eating disorders, schizophrenia, OCD, etc. etc. I’ve seen it help patients with such disorders when many other things, medicines or psychotherapies, have not helped much.

Anyway not trying to derail your thread. I just now think orgasm is less to do with hormones, and put my reasonings why. I could be completely wrong.
8
I just did a blood test and here are the results

FreeTestosterone: 240 (170 - 700 pmol/l)
Androstenedion: 5.3 (- 9.6 nmol/l)
Albumin: 41.5 (35.0 - 52.0 g/l)
bio-available Testosterone: 5.44 (4.00 - 20.00 nmol/l)
DHEAS: 7.8 (4.34 - 12.2 ?mol/l)
Estradiol: 69.0 (< 55 - 116 pmol/l)
LH/FSH Quotient: 1.6 (- 2)
Testosterone (Beckman): 21.2 (6.9 - 23.6 nmol/l)
FSH (Beckman): 5.0 (1.3 - 19.3 U/l)
LH (Beckman): 7.9 (1.2 - 8.6 U/l)
SHBG (Beckman): 82.0 (13.3 - 89.5 nmol/l)
free Androgen Index: 25.85 (31 - 116)

This is the first time I test all these sex hormones. I believe I am experiencing anhedonia for the past two years in a much more extreme form than in earlier years. I am 32. Does anyone have any theories about the relationship between my symptoms and these results?

My symptoms are that I have no sex drive, only occasionally do I wake up with wood, no spontaneous wood during the day. When I masturbate, I do feel orgasms, that vary in intensity from 2 to 7 on a good day. My sperm has changed form too in the last two years, becoming more liquid and having less total volume. I believe I have some sort of social anhedonia: I don't feel like interacting, and people interest me less and less. I don't have lack of motivation, as I work a lot in a field that pays me well and I keep rising and it is interesting, and I spend my evenings studying new things. But a romantic relationship seems impossible right now, both because of my lack of mental interest, and because I wouldn't even feel like doing the things you do when you like someone, like sex, or having an love connection.
9
Just found a very detailed anorgasmia presentation made in 2018:
https://grandroundsinurology.com/wp-content/uploads/2018/09/2018-9-12-SDU-Innovations-Male-Anorgasmia-From-No-To-Go-FINAL-Pastuszak.pdf


Here are all the pharmacology possbile treatments that have been listed:

Cabergoline
Bupropion
Oxytocin
Cyproheptadine
Buspirone
Pseudoephedrine
Ephedrine
Midodrine
Yohimbine
Amantadine
Apomorphine
Bethanechol
Loratadine
Reboxitine

Updated Keywords to search in Combination:

Quote
1. OCD (Obsessive Compulsive Disorder), Parkinsons, Tourettes, Trichotillomania, Parkinsons, Multiple Sclerosis, Bipolar, Depression, Anhedonia, Schizophrenia
2. NDMA, Histamine, NAC (N-acetylcysteine), Histidine, GABA, Sarcosine
3. DXM, Cyproheptadine, Cabergoline, Bupropion, Oxytocin, Buspirone, Pseudoephedrine, Ephedrine, Midodrine, Yohimbine, Amantadine, Apomorphine, Bethanechol, Loratadine, Reboxitine
4. Anorgasmia, Orgasm, Ejaculation, Ejaculatory, Sexual, Sexual Dysfunction, Libido

Now I know this keyword list is getting bigger and bigger and a lot of people have tried some of these. But the main thing you want to find connections with, is if any of them have effects on NDMA, Histamine, and  OCD. I believe these are the main factors to do with ejaculatory anhednoia.

Remember I'm on day 1 of my 5g of NAC. Lots of energy it seems lol.

But what this all comes down to if you want to get down to the possible cure/solution.

Try and take 2400mg (or more) of NAC a day for 3 months and report back here on any improvement with ejaculatory anhedonia and any other observations you see (whatever they may be, like anhedonia, aniexty, happiness, motivation, food tasting better, lessening of addictions etc..).
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https://www.ncbi.nlm.nih.gov/pubmed/25502486

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As-needed use of cyproheptadine for treatment of selective serotonin reuptake inhibitor-related female anorgasmia.

https://www.ncbi.nlm.nih.gov/pubmed/8919332
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Successful treatment of citalopram-induced anorgasmia by cyproheptadine.

This is the first report of the use of cyproheptadine to treat anorgasmia induced by citalopram, a highly selective serotonine reuptake inhibitor (SSRI). Total anorgasmia of a 47 year-old man who suffered from severe unipolar major depression was successfully treated without adverse effects. This case strengthens the impression that anorgasmia associated with SSRIs is related primarily to the serotonine reuptake inhibition and not to various receptor bindings of different compounds.

https://www.ncbi.nlm.nih.gov/pubmed/8665544
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Cyproheptadine treatment of sexual dysfunction induced by serotonin reuptake inhibitors.

Treatment of serotonin reuptake inhibitors (SRIs) is associated with sexual dysfunction. The cause of this dysfunction is unclear but may be related to stimulation of the serotonergic system. In the present article, we describe seven patients in whom iatrogenic sexual dysfunction induced by SRIs was treated with cyproheptadine, a 5HT-2 antagonist with antihistaminergic and adrenolytic properties. Seven obsessive-compulsive male patients, aged 29-54 years, who developed sexual dysfunction following treatment with SRIs (fluoxetine, fluvoxamine, and clomipramine) were instructed to take cyproheptadine (4-12 mg) 1-2 h before commencing sexual activity. Five of the seven patients displayed improvement in sexual function, although the improvement was transitory in two. The two remaining patients did not respond. All patients exhibited sedation on the day following cyproheptadine administration. Our preliminary observation suggests that some patients with sexual dysfunction associated with SRI treatment, mainly decreased libido and anorgasmia, may benefit from cyproheptadine administration. The role of 5HT-2 antagonists in SRI-induced sexual dysfunction merits further investigation.

https://www.ncbi.nlm.nih.gov/pubmed/7952994
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Successful treatment of fluvoxamine-induced anorgasmia by cyproheptadine.

https://www.ncbi.nlm.nih.gov/pubmed/1592848
Fluoxetine-induced yawning and anorgasmia reversed by cyproheptadine treatment.

https://www.ncbi.nlm.nih.gov/pubmed/1920732
Quote
Reversing anorgasmia associated with serotonin uptake inhibitors.

MeSH terms, Substances
Clomipramine/adverse effects
Cyproheptadine/therapeutic use*

Quote
Reversal of antidepressant activity of fluoxetine by cyproheptadine in three patients.

Three male patients are described in whom anorgasmia developed during treatment with fluoxetine for depression. During attempts to treat the anorgasmia with cyproheptadine, all three patients suffered a relapse of depressive symptoms. The possible mechanism of this effect is discussed in relation to serotonergic systems.

https://www.ncbi.nlm.nih.gov/pubmed/2880654
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Cyproheptadine and drug-induced anorgasmia.

https://www.ncbi.nlm.nih.gov/pubmed/3771824
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Cyproheptadine for imipramine-induced anorgasmia.

https://www.ncbi.nlm.nih.gov/pubmed/3697592
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Cyproheptadine and antidepressant-induced anorgasmia.

https://www.ncbi.nlm.nih.gov/pubmed/4039897
Quote
Reversal of MAOI-induced anorgasmia with cyproheptadine.



There's loads of studies, many from late 1980's on this anti-histmaine cyproheptadine helping reverse anorgasmia.

I'm assuming the anti-histamine is not available as much or has been replaced by newer ones.

But cyproheptadine is a new keyword! Google it in combinations with other keywords and see if we can find anything!

Updated keywords people should be researching in combinations:

Quote
1. OCD (Obsessive Compulsive Disorder), Parkinsons, Tourettes, Trichotillomania, Parkinsons, Multiple Sclerosis, Bipolar, Depression, Anhedonia, Schizophrenia
2. NDMA, Histamine, NAC (N-acetylcysteine), Histidine, GABA, DXM, Cyproheptadine
3. Anorgasmia, Orgasm, Ejaculation, Ejaculatory, Sexual, Sexual Dysfunction, Libido


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